Structure and Morphology of Lipid Nanoparticles for Nucleic Acid Drug Delivery: A Review

Lipid nanoparticles (LNPs) are a clinically proven platform for protecting and delivering nucleic acid-based therapeutics. These multicomponent particles self-assemble into a core-shell structure with the nucleic acid cargo encapsulated in its core. Despite considerable research efforts to establish structure-efficacy relationships, their morphological and structural characteristics─particularly their internal composition and distribution─remain elusive. This uncertainty arises from several factors, including challenges in characterization, the dynamic nature of LNPs, sample heterogeneity, and poorly understood formulation-structure relationships. This review highlights the current state of research on the…

• UF
  U.S. Food and Drug Administration

  Award: 75F40122C00200