Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing
Center for NanoScience · National Center for Nanoscience and Technology · +6 more institutions
Abstract
The regulation of the immune microenvironment is a key component of wound healing, where suitable wound dressings with skin immunoreactivity can favorably affect the immune process and promote the repairing progress. Therefore, we developed an injectable photo-cross-linkable composite hydrogel─oxidized astragalus polysaccharide and carboxymethyl chitosan/sodium methacrylated alginate and magnesium ions hydrogel (OAPS-CMC/SAMA-Mg2+, OCS) loaded with curcumin (Cur)-encapsulated Achyranthes bidentata supramolecular self-assemblies (NX SSA) (NX@Cur)─termed OCS/NX@Cur to synergistically accelerate skin repair. The astragalus polysaccharide-dominated hydrogel matrix provided a superior anti-inflammatory ability.…
Citation impact
- FWCI
- 36.27
- Percentile
- 100%
- References
- 65
Authors
10- MZMingyuan Zhao
Center for NanoScience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Center for Excellence in Education
- JXJiawei Xiang
Center for NanoScience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Center for Excellence in Education
- YMYuan Meng
Center for NanoScience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Center for Excellence in Education
- HSHuizhen Sun
Center for NanoScience, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences, Center for Excellence in Education
- WYWenxiao Yang
Yanshan University
Topics & keywords
- Self-healing hydrogels
- Polysaccharide
- Wound healing
- Traditional medicine
- Drug
- Self-healing
- Drug delivery
- Materials science
- Zero hunger