Implications of gut microbiota-mediated epigenetic modifications in intestinal diseases
South China Agricultural University · Southwest University · +1 more institution
Abstract
A). Importantly, mechanistic studies based on animal models or human cells have demonstrated that the gut microbiota, and other environmental factors, influence targeted gene expression and activate immune pathways through host epigenetic dysregulation, which are closely associated with the development of IBD and CRC. Furthermore, potential microbiome interventions, including probiotics, prebiotics and postbiotics, fecal microbiota transplantation (FMT), dietary modifications, and phage therapy, have been proposed as innovative therapeutic strategies to correct these abnormal epigenetic patterns associated with the diseases. Overall, addressing microbiome dysbiosis and its epigenetic consequences presents a…
Citation impact
- FWCI
- 27.06
- Percentile
- 100%
- References
- 277
Authors
9Topics & keywords
- Biology
- Epigenetics
- Gut flora
- Gut–brain axis
- Disease
- Inflammatory bowel disease
- Genetics
- Microbiome
- Zero hunger