Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer
Shanghai Medical College of Fudan University · Fudan University · +9 more institutions
Abstract
Background Pancreatic cancer exhibits limited clinical responses to immunotherapy, highlighting the need for new strategies to counteract its immunosuppressive microenvironment. Although metabolic reprogramming and epigenetic changes contribute to malignancy, the impact of lactate-driven histone lactylation on the tumour microenvironment (TME) has not been fully explored. Objective This study aims to investigate the role of histone lactylation in pancreatic cancer, focusing on its effects on cholesterol metabolism and antitumour immunity. Designs Global lactylome profiling was conducted to identify novel epigenetic mechanisms driven by lactate-induced histone lactylation. Mechanisms were investigated via RNA…
Citation impact
- FWCI
- 31.47
- Percentile
- 100%
- References
- 45
Authors
11- JYJing YangCorresponding
Shanghai Medical College of Fudan University, Fudan University, Fudan University Shanghai Cancer Center, Shanghai Cancer Institute
- XYXiaoning Yu
Shanghai Medical College of Fudan University, Fudan University, Fudan University Shanghai Cancer Center, Shanghai Cancer Institute
- MXMingming Xiao
Shanghai Medical College of Fudan University, Fudan University, Fudan University Shanghai Cancer Center, Shanghai Cancer Institute
- XHXu He
Dalian Medical University, First Affiliated Hospital of Dalian Medical University
- ZTZhen Tan
Qingdao University, Affiliated Hospital of Qingdao University
Topics & keywords
- Pancreatic cancer
- Cancer research
- Tumor microenvironment
- Biology
- Reprogramming
- Epigenetics
- Histone
- Immune system
- Good health and well-being