reviewChemical ReviewsJun 5, 2025Closed access

Noncovalent Aggregation for Diverse Properties in Hydrogels: A Comprehensive Review

University of California, Los Angeles · University of Washington

PubMed
Indexed incrossrefpubmed

Abstract

The rapid expansion of hydrogel research over recent decades has bridged fundamental chemistry and physics with advanced materials science applications. This field necessitates comprehensive and in-depth review and discussion of the diverse and rapidly expanding body of research, thereby providing a cohesive understanding that can drive future innovations and applications. This review delves into the role of noncovalent interactions in hydrogel aggregation, a critical mechanism for creating desired microstructures that enhance material properties. Inspired by natural molecular architecture, this paper explores how synthetic hydrogels exploit hydrogen bonds, hydrophobic interactions, and other noncovalent…

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