Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025

Epithelial-to-mesenchymal transition (EMT) is a crucial cellular process for embryogenesis, wound healing, and cancer progression. It involves a shift in cell interactions, leading to the detachment of epithelial cells and activation of gene programs promoting a mesenchymal state. EMT plays a significant role in cancer metastasis triggering tumor initiation and stemness, and activates metastatic cascades resulting in resistance to therapy. Moreover, reversal of EMT contributes to the formation of metastatic lesions. Metastasis still needs to be better understood functionally in its major but complex steps of migration, invasion, intravasation, dissemination, which contributes to the establishment of minimal…

• AN
  Arthritis National Research Foundation
• WS
  Wilhelm Sander-Stiftung
• DO
  Department of Biotechnology, Ministry of Science and Technology, India
• IC
  Indian Council of Medical Research
• AK
  Alfried Krupp von Bohlen und Halbach-Stiftung
• SA
  Science and Engineering Research Board

  Award: JCB/2023/000011