Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

ABSTRACT The pursuit of developing groundbreaking pro‐regenerative therapies to expedite skin wound healing persists as a formidable challenge. Peptide RL‐QN15, emerges as a highly promising candidate for the first pro‐regenerative drug derived from amphibian skin, offering a glimmer of hope for innovative healing treatments. Yet, there is an urgent need for intensified research efforts to propel RL‐QN15 from a molecular entity to a viable drug candidate, particularly in unraveling the mechanisms underlying its exceptional pro‐healing efficacy. In the current research, our results revealed that RL‐QN15 significantly enhanced the proliferation, migration, stemness, and epithelial‐to‐mesenchymal transition of…

• NN
  National Natural Science Foundation of China

  Awards: 32060212, 81760648, 32360138, 32301054