Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
Shanghai Jiao Tong University · Shanghai Ninth People's Hospital · +1 more institution
Abstract
Mitochondria are the energy production centers in cells and have unique genetic information. Due to the irreplaceable function of mitochondria, mitochondrial dysfunction often leads to pathological changes. Mitochondrial dysfunction induces an imbalance between oxidation and antioxidation, mitochondrial DNA (mtDNA) damage, mitochondrial dynamics dysregulation, and changes in mitophagy. It results in oxidative stress due to excessive reactive oxygen species (ROS) generation, which contributes to cell damage and death. Mitochondrial dysfunction can also trigger inflammation through the activation of damage-associated molecular patterns (DAMPs), inflammasomes and inflammatory cells. Besides, mitochondrial…
Citation impact
- FWCI
- 276.69
- Percentile
- 100%
- References
- 570
Authors
3Topics & keywords
- Oxidative stress
- Inflammation
- Mitochondrion
- Oxidative phosphorylation
- Medicine
- Bioinformatics
- Biology
- Immunology