Nanozyme‐Reinforced Hydrogel Spray as a Reactive Oxygen Species‐Driven Oxygenator to Accelerate Diabetic Wound Healing

The accumulation of reactive oxygen species (ROS) and poor oxygen supply are two prominent factors of the inflammatory microenvironment that delay diabetic wound healing. However, current clinical treatments cannot achieve effective ROS scavenging and sustained oxygenation. Herein, a ROS-driven oxygenation hydrogel (OxyGel) spray that integrates a multifunctional nanozyme with a dynamically crosslinked sprayable hydrogel matrix is presented. The nanozyme, which is fabricated based on the ceria-zoledronic acid nanoparticles modified with tannic acid (TCZ nanozymes), can mimic the cascade catalytic activities of superoxide dismutase (SOD) and catalase (CAT) to effectively scavenge ROS while generating oxygen.…

• NN
  National Natural Science Foundation of China

  Awards: 32271385, 82172406
• NK
  National Key Research and Development Program of China

  Award: 2024YFB3814900
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2024ZYGXZR086