Immune microenvironment in hepatocellular carcinoma: from pathogenesis to immunotherapy
Sorbonne Université · National Institute on Alcohol Abuse and Alcoholism · +12 more institutions
Abstract
Abstract Hepatocellular carcinoma (HCC) is an increasingly prevalent and deadly disease that is initiated by different etiological factors, such as alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatohepatitis (MASH), viral hepatitis, and other hepatotoxic and hepatocarcinogenic agents. The tumor microenvironment (TME) of HCC is characterized by several different fibroblastic and immune cell types, all of which affect the initiation, progression and metastasis of this malignant cancer. This complex immune TME can be divided into an innate component that includes macrophages, neutrophils, dendritic cells, myeloid-derived suppressor cells, mucosal-associated invariant T cells, natural…
Citation impact
- FWCI
- 35.50
- Percentile
- 100%
- References
- 449
Authors
7- DADeniz Akyol SeyhanCorresponding
Sorbonne Université, National Institute on Alcohol Abuse and Alcoholism, Physiopathologie et Epidémiologie des Maladies Respiratoires
- MAManon Allaire
Inserm, Université Paris Cité, Sorbonne Université, Centre de Recherche des Cordeliers, Immunité et Cancer, Pitié-Salpêtrière Hospital
- YFYaojie Fu
National Institute on Alcohol Abuse and Alcoholism
- FCFilomena Conti
Sorbonne Université, Pitié-Salpêtrière Hospital
- XWXin Wei Wang
National Cancer Institute, Center for Cancer Research
Topics & keywords
- Hepatocellular carcinoma
- Immunotherapy
- Pathogenesis
- Immune system
- Tumor microenvironment
- Immunology
- Immune escape
- Medicine
- Good health and well-being