Senescence in cancer
Università della Svizzera italiana · Institute of Oncology Research · +4 more institutions
Abstract
Cellular senescence is a state of stable cell-cycle arrest induced by various intrinsic and extrinsic stressors, serving as a protective mechanism to prevent the proliferation of damaged cells. While this process is crucial for tissue homeostasis and tumor suppression, the progressive accumulation of senescent cells (SnCs) over time is implicated in age-related pathologies, including immune dysfunction and cancer. In oncology, senescence plays a paradoxical role: it can inhibit tumor development by halting the growth of potentially malignant cells, yet it may also facilitate tumor progression through the senescence-associated secretory phenotype (SASP). This review explores the defining features of senescence…
Citation impact
- FWCI
- 54.55
- Percentile
- 100%
- References
- 211
Authors
16Topics & keywords
- Senescence
- Context (archaeology)
- Cancer
- Immune system
- Biology
- Mechanism (biology)
- Cancer research
- Cancer cell
- Good health and well-being