reviewInternational Journal of Medical SciencesMay 31, 2025GOLD OA

Large Language Models in Medicine: Applications, Challenges, and Future Directions

Capital Medical University · Peng Cheng Laboratory · +2 more institutions

PubMed
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Abstract

In recent years, large language models (LLMs) represented by GPT-4 have developed rapidly and performed well in various natural language processing tasks, showing great potential and transformative impact. The medical field, due to its vast data information as well as complex diagnostic and treatment processes, is undoubtedly one of the most promising areas for the application of LLMs. At present, LLMs has been gradually implemented in clinical practice, medical research, and medical education. However, in practical applications, medical LLMs still face numerous challenges, including the phenomenon of hallucination, interpretability, and ethical concerns. Therefore, in-depth exploration is still needed in…

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