Rational Design of Type‐I Photodynamic Agents

Type-I photodynamic agents can not only produce cytotoxic reactive oxygen species, but also directly damage biomolecules through electron/hydrogen transfer process, exhibiting reduced dependence on oxygen concentration in photodynamic therapy (PDT). The rational design of Type-I photodynamic agents has attracted increasing attention. This minireview provides a comprehensive overview of Type-I PDT and its advantages in treating hypoxic tumors. It systematically outlines two complementary design strategies: i) thermodynamic modulation through molecular engineering to block the Type-II energy transfer pathway, and ii) kinetic enhancement of electron/hydrogen transfer to favor the Type-I mechanism. Finally, key…

• NN
  National Natural Science Foundation of China

  Awards: 22301067, 22231001 22301017 22477009 22177014 22301067, 22177014, 22231001, 22301017, 22477009
• CP
  China Postdoctoral Science Foundation

  Award: 2023M730287
• NP
  National Postdoctoral Program for Innovative Talents

  Award: BX20230046
• FR
  Fundamental Research Funds for the Central Universities