Oxidative Stress and Inflammation: Drivers of Tumorigenesis and Therapeutic Opportunities
Dongguan University of Technology · Guangzhou Eighth People's Hospital · +1 more institution
Abstract
As two pivotal regulatory factors in cancer biology, oxidative stress and inflammation interact dynamically through complex network mechanisms to influence tumor initiation, progression, and treatment resistance. Oxidative stress induces genomic instability, oncogenic signaling activation, and tumor microenvironment (TME) remodeling via the abnormal accumulation of reactive oxygen species (ROS) or reactive nitrogen species (RNS). Conversely, inflammation sustains malignant phenotypes by releasing pro-inflammatory cytokines and chemokines and promoting immune cell infiltration. These processes create a vicious cycle via positive feedback loops whereby oxidative stress initiates inflammatory signaling, while the…
Citation impact
- FWCI
- 35.82
- Percentile
- 100%
- References
- 443
Authors
11Topics & keywords
- Oxidative stress
- Inflammation
- Carcinogenesis
- Cancer research
- Bioinformatics
- Medicine
- Immunology
- Biology