Mitochondrial dysfunction in the regulation of aging and aging-related diseases
Inner Mongolia University · Ningxia University · +1 more institution
Abstract
Aging is an irreversible physiological process that progresses with age, leading to structural disorders and dysfunctions of organs, thereby increasing the risk of chronic diseases such as neurodegenerative diseases, diabetes, hypertension, and cancer. Both organismal and cellular aging are accompanied by the accumulation of damaged organelles and macromolecules, which not only disrupt the metabolic homeostasis of the organism but also trigger the immune response required for physiological repair. Therefore, metabolic remodeling or chronic inflammation induced by damaged tissues, cells, or biomolecules is considered a critical biological factor in the organismal aging process. Notably, mitochondria are…
Citation impact
- FWCI
- 49.30
- Percentile
- 100%
- References
- 406
Authors
12Topics & keywords
- Inflammation
- Senescence
- Mitochondrion
- Biology
- Immune system
- Cell biology
- Mitophagy
- Crosstalk
- Zero hunger