Caspases as master regulators of programmed cell death: apoptosis, pyroptosis and beyond
Gangnam Severance Hospital · Pohang University of Science and Technology
Abstract
Caspases are crucial regulators of programmed cell death, mediating pathways such as apoptosis, pyroptosis, necroptosis and ferroptosis. Their activity is intricately controlled by epigenetic modifications, molecular interactions and post-translational changes, reflecting their central role in cellular homeostasis and disease mechanisms. Dysregulated caspase functions are linked to a wide array of conditions, including cancer, neurodegenerative disorders and inflammatory diseases, establishing their importance as potential therapeutic targets. The roles and regulation of caspases across subcellular compartments and their molecular interactions provide critical insights into the complexity of programmed cell…
Citation impact
- FWCI
- 44.41
- Percentile
- 100%
- References
- 126
Authors
5Topics & keywords
- Pyroptosis
- Necroptosis
- Caspase
- Programmed cell death
- Cell biology
- Apoptosis
- Intrinsic apoptosis
- Biology
- Good health and well-being