Tryptophan metabolism as a target in gut microbiota, ageing and kidney disease
Zhejiang Chinese Medical University · China-Japan Friendship Hospital
Abstract
Aromatic amino acid tryptophan metabolism, particularly three main metabolism pathways including kynurenine, serotonin and indole-derived pathways are under the direct or indirect modulation of host-microbiota crosstalk in human physiology. Tryptophan metabolism is involved in the regulation of aging, immunity and intestinal homeostasis. Dysregulation of tryptophan metabolism ranging from bowel disease to kidney disease allow us to therapeutic targeting the tryptophan metabolism. This review summarizes recent advances in physiological and pathophysiological roles of tryptophan metabolism in health and disease such as ageing-related disease, bowel disease and renal disease. Decoding the sophisticated imbalance…
Citation impact
- FWCI
- 19.19
- Percentile
- 100%
- References
- 0
Authors
5Topics & keywords
- Ageing
- Gut flora
- Biology
- Metabolism
- Tryptophan
- Disease
- Microbiology
- Medicine
- Zero hunger