articleJournal of the American Chemical SocietyJun 26, 2025Closed access

Dual Active Sites on Cu/Cu 2 O Heterostructures for the Cascade Electrocatalytic Synthesis of Amino Acids

Chinese Academy of Sciences · Shanghai Institute of Ceramics · +3 more institutions

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Abstract

Electrocatalytic C–N coupling enables the efficient and sustainable production of amino acids. However, it suffers from complex reaction pathways and intense adsorption competition between the reactants and intermediates on a single site. Herein, we report a cascade catalytic strategy on Cu/Cu2O heterostructures for the electrosynthesis of amino acids from nitrate and keto acids. The catalysts are capable of producing a wide range of amino acids (including alanine, glycine, leucine, and glutamic acid), achieving an impressively high Faradaic efficiency of up to 75.78% and a yield of as high as 478.89 mmol h–1gcat–1 for alanine. Mechanism explorations disclose the reconstruction of CuO/C electrocatalysts into…

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