Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells

The liver is a central hub in lipid, carbohydrate and protein metabolism and protects against gut-derived antigens and toxins. The etiology of liver diseases includes altered metabolism, viral infections, autoimmunity, toxins and genetic alterations. Liver-resident cells, including hepatocytes, biliary epithelial cells, endothelial cells, and hepatic stellate cells, are essential for liver function and homeostasis but may also drive the development of inflammation, fibrosis, cirrhosis and liver cancer via interactions with immune cells. This review highlights the often-underappreciated contributions of epithelial, endothelial and mesenchymal liver cells in regulating inflammation and immunity across various…

• DF
  Deutsche Forschungsgemeinschaft

  Awards: ID 403224013, SFB1382, Project-ID 403224013, 403224013, SFB1382
• NI
  National Institutes of Health

  Awards: 5R01DK128955, R01 DK136511, 5P30DK132710, NIH P30 DK084567, P30 DK084567, DK084567, DK136511, 5R01CA262424, NIH R01 DK136511
• CF
  Center for Cell Signaling in Gastroenterology, Mayo Clinic

  Awards: P30 DK084567, DK084567