Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation

Mitochondrial dysfunction contributes to aging and diseases like neurodegeneration and cardiovascular disorders. Mitochondria transfer and transplantation (MTT) represent promising therapeutic strategies aimed at restoring cellular function by introducing functional mitochondria into damaged cells. However, challenges like transfer efficiency, stability, and cellular integration limit clinical application. Recent biotechnological advances-such as liposomes, extracellular vesicles, and surface modifications-enhance mitochondrial protection, targeting, and biocompatibility. This Perspective highlights recent progress in MTT, its therapeutic potential, and current limitations. We also discuss the need for…

• BC
  Breast Cancer Research Foundation
• EC
  European Commission

  Award: ECS00000022
• CU
  China University of Petroleum, Beijing
• TB
  Türkiye Bilimsel ve Teknolojik Araştırma Kurumu

  Award: 323S336
• NI
  National Institutes of Health