Central-peripheral neuroimmune dynamics in psychological stress and depression: insights from current research

Psychological stress plays a critical role in the onset of depression by activating neuroimmune and endocrine responses, leading to dysregulation of the hypothalamic-pituitary-adrenal axis and increased inflammation. This imbalance impacts key brain regions involved in mood regulation, such as the prefrontal cortex, hippocampus, and amygdala, contributing to the development of depressive symptoms. Moreover, stress induces immune dysregulation and inflammation in peripheral organs, including the gut, spleen, liver, lungs, and heart, which can result in metabolic disorders, cardiovascular disease, and immune dysfunction. Chronic stress also disrupts gut microbiota and alters the gut-brain axis via the vagus…

• P2
  Project 211

  Award: CXJD2019008