Reprogramming Immunodeficiency in Lung Metastases via PD-L1 siRNA Delivery and Antigen Capture of Nanosponge-Mediated Dendritic Cell Modulation

Infiltration of cytotoxic T lymphocytes into hypovascular metastases offers significant potential for suppressing even the most intractable metastatic tumors, with dendritic cells (DCs) serving as pivotal initiators of antitumor immune responses during immunotherapy. However, the immune-privileged nature of hypovascular lung metastases combined with the inherently low immunogenicity of tumor clusters poses substantial barriers to effective lymphocyte recruitment. Here, a pH-responsive lung metastatic-targeted catalyst containing the tumor penetration polymer (TP)/solid lipids (SL)-coated Prussian blue (TP-SL@PB)-enhanced PD-L1 siRNA delivery and self-cascade antigen capture is developed for reprogramming…

• NH
  National Health Research Institutes

  Award: NHRI-EX113-11111EI
• NT
  National Tsing Hua University

  Awards: 112F7MDHE1, 112Q2715E1, 112F7MDKE1
• NS
  National Science and Technology Council

  Awards: NSTC 112-2321-B-007-003 -, NSTC 112-2314-B-007 -005 -MY3, MOST 111-2314-B-007 -003 -MY3