reviewSignal Transduction and Targeted TherapyJul 9, 2025GOLD OA

Glioblastoma at the crossroads: current understanding and future therapeutic horizons

SSShilpi SinghDDDevanjan DeyDBDebashis BarikIMIteeshree MohapatraSKStefan Kim

University of Minnesota · International Institute of Information Technology, Hyderabad · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Glioblastoma (GBM) remains the most aggressive and lethal brain tumor in adults and poses significant challenges to patient survival. This review provides a comprehensive exploration of the molecular and genetic landscape of GBM, focusing on key oncogenic drivers, such as epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), and the PI3K/AKT/mTOR pathway, which are critical for tumorigenesis and progression. We delve into the role of epigenetic alterations, including DNA methylation and histone modifications, in driving therapy resistance and tumor evolution. The tumor microenvironment is known for its pivotal role in immune evasion, with tumor-associated macrophages,…

Citation impact

147
total citations
FWCI
179.15
Percentile
100%
References
500
Citations per year

Authors

10

Topics & keywords

Topics
Keywords
  • Tumor microenvironment
  • Cancer research
  • Epigenetics
  • PI3K/AKT/mTOR pathway
  • Biology
  • Reprogramming
  • Glioma
  • Immune system
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