Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions
Hanyang University Medical Center · Hanyang University · +5 more institutions
Abstract
Recent advances in our understanding of non-cell-autonomous mechanisms in neurodegenerative diseases (NDDs) have highlighted microglial dysfunction as a core driver of disease progression. Conditions such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and frontotemporal dementia (FTD) share features of impaired microglial phagocytosis, chronic neuroinflammation, and metabolic dysregulation. These insights have prompted new therapeutic strategies targeting microglial function and emphasized the need for reliable biomarkers to monitor disease progression and treatment response. Well-established therapeutic targets, such as triggering receptor expressed on myeloid…
Citation impact
- FWCI
- 28.60
- Percentile
- 100%
- References
- 412
Authors
7Topics & keywords
- Microglia
- Medicine
- Neurology
- Neuroscience
- Current (fluid)
- Inflammation
- Psychology
- Immunology