Pattern recognition receptors: function, regulation and therapeutic potential
Central South University · National Clinical Research · +6 more institutions
Abstract
Pattern recognition receptors (PRRs) are sensors in the immune system, detecting pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). They serve as essential links between the innate and adaptive immune responses, initiating defense mechanisms against pathogens and maintaining immune homeostasis. This review examines the classification, structure, and signaling cascades of key PRR families, including toll-like receptors (TLRs), C-type lectin receptors (CLRs), nucleotide-binding oligomerization domain-like receptors (NLRs), AIM2-like receptors (ALRs), and others. It explores the dual roles of PRRs in immune defense and regulation, particularly through inhibitory PRRs…
Citation impact
- FWCI
- 90.86
- Percentile
- 100%
- References
- 609
Authors
6- RCRuochan ChenCorresponding
Central South University, National Clinical Research, Xiangya Hospital Central South University
- JZJu Zou
Central South University, National Clinical Research Center for Digestive Diseases, Xiangya Hospital Central South University
- JCJiawang Chen
Central South University, National Clinical Research Center for Digestive Diseases, Xiangya Hospital Central South University, Hainan Medical University
- XYXiao Yan Zhong
Central South University, National Clinical Research Center for Digestive Diseases, Xiangya Hospital Central South University
- RKRui Kang
Southwestern Medical Center, Southwestern Medical Center, The University of Texas Southwestern Medical Center
Topics & keywords
- Function (biology)
- Receptor
- Computational biology
- Biology
- Medicine
- Cell biology
- Biochemistry
- Good health and well-being