Short-chain fatty acids (SCFAs) in gut health: Implications for drug metabolism and therapeutics

Short-chain fatty acids (SCFAs) are the primary energy substrate for colonocytes, synthesized in the gut when gut microbiomes ferment the dietary fibers. SCFAs play crucial roles in maintaining gut homeostasis and exerting systemic effects beyond the gastrointestinal tract. Liver disorders, cardiovascular, diabetes, and obesity like metabolic syndromes are strongly associated with these metabolites’ imbalance. Determining the genetic variability, diet-gene interactions, and microbiome diversity in SCFA production is essential for creation of targeted interventions to optimize gut health and mitigate disease risk. The present review aims to elucidate the nutrigenomics and nitrogenic analysis to improve SCFAs to…