The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging
BioVentures (United States) · University of California, San Francisco · +49 more institutions
Abstract
More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment options remain limited due to disease heterogeneity, prolonged preclinical and prodromal phases, poor understanding of disease mechanisms, and diagnostic challenges. Identifying novel biomarkers is crucial for improving early detection, prognosis, staging and subtyping of these conditions. High-dimensional molecular studies in biofluids ('omics') offer promise for scalable biomarker discovery, but challenges in assembling large, diverse datasets hinder progress. To address this, the Global Neurodegeneration Proteomics…
Citation impact
- FWCI
- 69.98
- Percentile
- 100%
- References
- 26
Authors
52Topics & keywords
- Neurodegeneration
- Amyotrophic lateral sclerosis
- Disease
- Biomarker discovery
- Biomarker
- Proteomics
- Frontotemporal dementia
- Medicine
- Partnerships for the goals
Funding
- SHSun Health Foundation
- VUVanderbilt University
- EUEmory University
- HYHelsingin Yliopisto
- JHJohns Hopkins University
- WTWellcome Trust
- VUVanderbilt University Medical Center
- AGAustralian Government
- GFGHR Foundation
- ICImperial College London
- UCUniversity College London
- ECEuropean Commission
- GDGeneralitat de Catalunya
- LULunds Universitet
- KOKnut och Alice Wallenbergs Stiftelse
- VVetenskapsrådet
- UDUniversité de Montréal
- KGKonung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- SFScience for Life Laboratory
- ANAlzheimer Nederland
- SUSkånes universitetssjukhus
- CDCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- NINational Institutes of Health
- JAJohnson and Johnson
- SOSchool of Medicine, Emory University
- UOUniversity of California, San Francisco
- PParkinsonfonden
- SOSchool of Medicine, Indiana University
- WTWu Tsai Neurosciences Institute, Stanford University
- MRMedical Research Council
- IDInstituto de Salud Carlos III
- SOSchool of Public Health, Imperial College London
- FOFaculty of Medicine and Health, University of Sydney
- NINational Institute on Aging
- NINational Institute of Neurological Disorders and Stroke
- JRJanssen Research and Development
- NCNational Center for Advancing Translational Sciences
- RPRobert Packard Center for ALS Research, Johns Hopkins University