Mass Spectrometry Imaging

Mass spectrometry imaging (MSI) maps the spatial distributions of chemicals on chemically complex surfaces. MSI offers unrivaled sensitivity and information density with each pixel comprising a mass spectrum. Over the past three decades, numerous technological developments have enabled MSI to evolve into a mainstream technique for untargeted molecular and elemental imaging with wide-spread applications ranging from material analysis to life sciences and clinical diagnostics. Here, we review the field of MSI with a focus on key technological advancements. We examine different image acquisition modes and the most popular ionization methods in MSI, including matrix-assisted laser desorption/ionization (MALDI),…

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  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Award: 184.034.014