Advances in Peptidomimetics for Next-Generation Therapeutics: Strategies, Modifications, and Applications
Queen's University Belfast · Imperial College London · +5 more institutions
Abstract
Over the past two decades, peptide drug discovery has experienced a remarkable renaissance, with organic chemistry and biotechnology emerging as pivotal tools for developing peptidomimetics that exhibit improved stability, specificity, and bioavailability compared to conventional peptides. This review systematically examines methodologies for modifying peptide backbones to achieve targeted properties, highlighting recent advances facilitated by modern biotechnological innovations for novel molecular transformations. Additionally, the review emphasizes the practical applications of peptides and peptidomimetics, showcasing their successful integration into medicine and pharmacology. This manuscript evaluates…
Citation impact
- FWCI
- 34.30
- Percentile
- 100%
- References
- 473
Authors
4- LLLucia LombardiCorresponding
Queen's University Belfast, Imperial College London
- VDValentina Del Genio
Federico II University Hospital, University of Naples Federico II
- FAFernando Alberício
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Universitat de Barcelona, University of KwaZulu-Natal
- DRDaryl R. Williams
Imperial College London
Topics & keywords
- Chemistry
- Peptidomimetic
- Computational biology
- Nanotechnology
- Biochemistry