reviewFrontiers in PharmacologyJul 30, 2025GOLD OA

Impact of extraction techniques on phytochemical composition and bioactivity of natural product mixtures

Changchun University of Chinese Medicine · Gwangju Institute of Science and Technology · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Extraction methods critically influence the phytochemical profile and bioactivity of natural product mixtures, affecting their efficacy as therapeutic agents. This review assesses the impact of various extraction techniques-such as solvent-based extraction, ultrasound-assisted extraction, and enzymatic extraction-on the composition of bioactive compounds in plant extracts. We discuss how extraction parameters modify the bioactivity profiles, influencing their application in pharmaceutics and nutrition. This review critically analyzes these techniques with a special focus on integrated (hybrid) strategies, revealing that while advanced methods like ultrasound-assisted extraction and microwave-assisted…

Citation impact

74
total citations
FWCI
65.57
Percentile
100%
References
180
Citations per year

Authors

11

Topics & keywords

Keywords
  • Extraction (chemistry)
  • Phytochemical
  • Biochemical engineering
  • Natural product
  • Pharmaceutics
  • Biotechnology
  • Traditional medicine
  • Chromatography
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