articleNature MedicineAug 4, 2025HYBRID OA

Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial

SJSamuel J. DickenFCFriedrich C. JassilABAdrian BrownMKMonika KalisCSC Stanley

University of East London · National Institute for Health and Care Research · +12 more institutions

PubMed
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Abstract

Abstract Ultraprocessed food (UPF) consumption is associated with noncommunicable disease risk, yet no trial has assessed its health impact within the context of national dietary guidelines. In a 2 × 2 crossover randomized controlled feeding trial, 55 adults in England (body mass index ≥25 to <40 kg m −2 , habitual UPF intake ≥50% kcal day −1 ) were provided with two 8-week ad libitum diets following the UK Eatwell Guide: (1) minimally processed food (MPF) and (2) UPF, in a random order. Twenty-eight people were randomized to MPF then UPF, and 27 to UPF then MPF; 50 participants comprised the intention-to-treat sample. The primary outcome was the within-participant difference in percent weight change (%WC)…

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Topics & keywords

Topics
Keywords
  • Medicine
  • Randomized controlled trial
  • Context (archaeology)
  • Crossover study
  • Confidence interval
  • Weight loss
  • Body mass index
  • Adverse effect
UN Sustainable Development Goals
  • Zero hunger
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