Immunosenescence: signaling pathways, diseases and therapeutic targets
Huazhong University of Science and Technology · Sichuan University · +2 more institutions
Abstract
Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of proinflammatory cytokines in aged immune cells. Chronic inflammation contributes to a variety of age-related diseases, such as neurodegenerative disease, cancer, infectious disease, and autoimmune diseases. Although not fully understood, recent studies contribute greatly to uncovering the underlying mechanisms of immunosenescence at the molecular and cellular levels. Immunosenescence is associated with dysregulated signaling pathways (e.g., overactivation of the NF-κB…
Citation impact
- FWCI
- 40.63
- Percentile
- 100%
- References
- 503
Authors
9Topics & keywords
- Immunosenescence
- Immunology
- Immune system
- Biology
- Disease
- Proinflammatory cytokine
- Medicine
- Inflammation
- Zero hunger