Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
Chinese University of Hong Kong · Chinese University of Hong Kong, Shenzhen · +2 more institutions
Abstract
Humanized mice and autologous patient-derived CRC organoids-CTLs co-culture system. To summarize, C. butyricum is a promising adjuvant to augment ICB therapy.
Citation impact
- FWCI
- 26.47
- Percentile
- 100%
- References
- 48
Authors
14- MXMingxu XieCorresponding
Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen
- KYKai Yuan
Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen
- YZYongxin Zhang
Sun Yat-sen University, Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen, The First Affiliated Hospital, Sun Yat-sen University
- YZYating Zhang
Sun Yat-sen University, Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen, The First Affiliated Hospital, Sun Yat-sen University
- RZRuyi Zhang
Chinese University of Hong Kong, Chinese University of Hong Kong, Shenzhen
Topics & keywords
- Clostridium butyricum
- Cancer research
- Colorectal cancer
- CD8
- Cytotoxic T cell
- T cell
- PI3K/AKT/mTOR pathway
- Immunotherapy
- Good health and well-being
Funding
- CUChinese University of Hong KongAwards: 3133344, 3134277, 3135509
- IAInnovation and Technology FundAward: ITS/177/21FP
- NKNational Key Research and Development Program of ChinaAward: 2020YFA0509200 / 2020YFA0509203
- NKNational Key Research and Development Program of China Stem Cell and Translational Research