Beyond the gut: decoding the gut–immune–brain axis in health and disease
Pohang University of Science and Technology · Yonsei University · +2 more institutions
Abstract
Emerging research underscores the pivotal role of the gut-immune-brain axis, a dynamic bidirectional communication system involving intricate interactions between the gut microbiota, immune responses, and the central nervous system. Gut microbes and their metabolites have profound effects on immune and neurological homeostasis, influencing the development and function of multiple physiological systems. Disruption of the composition of the gut microbiota and barrier integrity has been implicated in various neurological and psychiatric disorders, including autism spectrum disorder, Alzheimer's disease, Parkinson's disease, depression, and anxiety. Most insights into these host-microbiota interactions come from…
Citation impact
- FWCI
- 44.41
- Percentile
- 100%
- References
- 380
Authors
4- JCJohn Chulhoon ParkCorresponding
Pohang University of Science and Technology
- LCLeechung Chang
Yonsei University
- HKHo‐Keun Kwon
Pohang University of Science and Technology, Yonsei University, Yonsei University Health System
- SISin‐Hyeog Im
Pohang University of Science and Technology, Advanced Institute of Convergence Technology
Topics & keywords
- Gut–brain axis
- Gut flora
- Immune system
- Neuroscience
- Microbiome
- Disease
- Autism
- Biology
Funding
- NRNational Research Foundation
- PUPohang University of Science and Technology
- YUYonsei University
- NRNational Research Foundation of KoreaAwards: RS-2024-00361620, RS-2019-NR040072, RS-2024-00345575, RS-2024-00438443, RS-2025-00561456
- MOMinistry of Science and ICT, South Korea
- YUYonsei University College of Medicine