reviewChemical ReviewsAug 21, 2025Closed access

Therapeutic Hydrogels: Properties and Biomedical Applications

3M (United States) · University of Toronto · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Hydrogels have emerged as versatile therapeutic platforms with immense potential for treating various diseases, due to their tunable properties and biocompatibility. Recent innovations, including injectable, self-assembling, and bioadhesive hydrogels, have broadened their biomedical applications, driven by advancements in materials chemistry. This review systematically examines the role of chemical principles in designing and customizing therapeutic hydrogels, with a focus on hydrogelation mechanisms, swelling ratios, mechanical properties, and biological interactions. By highlighting key studies in this field, this review explores how chemical chain modifications, cross-linking strategies, and cargo delivery…

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