Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies

Mesenchymal stem cells (MSCs) have emerged as a highly promising strategy in regenerative medicine due to their self-renewal, pluripotency and immunomodulatory properties. MSCs are nonhematopoietic, multipotent stem cells that can differentiate into various mesodermal lineages and modulate the immune system. The therapeutic potential of MSCs from different tissues has been widely explored in preclinical models and clinical trials for human diseases, ranging from autoimmune diseases and inflammatory disorders to neurodegenerative diseases and orthopedic injuries. The therapeutic effects of MSCs can be mediated through the release of bioactive molecules, including growth factors, cytokines, and extracellular…

• NN
  National Natural Science Foundation of China

  Awards: 82261160395, 82230081, 2017B030301018, 82004395, 82250710175, 82430078, 82230081, 82250710175, 82261160395, 81991513, 82172375
• SM
  Southern Medical University
• GU
  Guangzhou University of Chinese Medicine
• GU
  Guangzhou University
• SF
  Shenzhen Fundamental Research Program

  Award: JCYJ20220818100617036