Oxidative stress in cancer: from tumor and microenvironment remodeling to therapeutic frontiers
Central South University · National Clinical Research Center for Digestive Diseases · +5 more institutions
Abstract
Oxidative stress is a pathological condition of redox signaling dysregulation and macromolecular oxidative damage arising from elevated ROS levels. Oxidative stress interacts with tumor cell growth regulation and tumor microenvironment remodeling, and has been a critical hallmark of cancer. Targeting oxidative stress has garnered great attention in cancer therapy development. However, it is still challenging due to the complexity and heterogeneity of oxidative stress regulation across different cancers, and this encourages a comprehensive understanding of the oxidative stress network in cancers to overcome this obstacle. Therefore, we introduced the oxidative stress generation and regulatory network within…
Citation impact
- FWCI
- 44.07
- Percentile
- 100%
- References
- 639
Authors
9- XLXisong Liang
Central South University, National Clinical Research Center for Digestive Diseases, Xiangya Hospital Central South University
- JWJiadi Weng
Central South University, National Clinical Research Center for Digestive Diseases, Xiangya Hospital Central South University
- ZYZhongyi You
Central South University, National Clinical Research Center for Digestive Diseases, Xiangya Hospital Central South University
- YWYang Wang
Central South University, National Clinical Research Center for Digestive Diseases, Xiangya Hospital Central South University
- JWJie Wen
Central South University, National Clinical Research Center for Digestive Diseases, Xiangya Hospital Central South University
Topics & keywords
- Oxidative stress
- Tumor microenvironment
- Cancer
- Nanomedicine
- Cancer research
- Cancer cell
- Biology
- Immunotherapy