Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation
Inserm · Université de Lille · +37 more institutions
Abstract
The appropriate antithrombotic regimen for patients with chronic coronary syndrome who are at high atherothrombotic risk and receiving long-term oral anticoagulation remains unknown.
We conducted a multicenter, double-blind, randomized, placebo-controlled trial in France involving patients with chronic coronary syndrome who had undergone a previous stent implantation (>6 months before enrollment) and were at high atherothrombotic risk and currently receiving long-term oral anticoagulation. The patients were randomly assigned in a 1:1 ratio to receive aspirin (100 mg once daily) or placebo; all the patients continued to receive their current oral anticoagulation therapy. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, stroke, systemic embolism, coronary revascularization, or acute limb ischemia. The key safety outcome was major bleeding.
Citation impact
- FWCI
- 50.89
- Percentile
- 100%
- References
- 24
Authors
20- GLGilles LemesleCorresponding
Inserm, Université de Lille, Institut Pasteur de Lille, Centre Hospitalier Universitaire de Lille, Alliance nationale pour les sciences de la vie et de la santé
- RDRomain Didier
Inserm, Université de Bretagne Occidentale, Centre Hospitalier Régional Universitaire de Brest, Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
- PGPhilippe Gabríel Steg
Inserm, Université Paris Cité, Sorbonne Paris Cité, Assistance Publique – Hôpitaux de Paris, Paris Cardiovascular Research Center, Hôpital Bichat-Claude-Bernard, Alliance nationale pour les sciences de la vie et de la santé
- TSTabassome Simon
Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Antoine, Paris Cardiovascular Research Center, Alliance nationale pour les sciences de la vie et de la santé, Laboratoire Médiations
- GMGilles Montalescot
ActionAid, Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris Cardiovascular Research Center, Institut Carnot ARTS, Laboratoire Médiations, Action Contre la Faim
Topics & keywords
- Aspirin
- Medicine
- Acute coronary syndrome
- Internal medicine
- Cardiology
- Myocardial infarction