articleFrontiers in Cellular and Infection MicrobiologyAug 14, 2025GOLD OA

Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria

HOHazim O. KhalifaAOAtef OreibyTMTemesgen MohammedMAMohamed Abdel‐HamidENEssam Nageh Sholkamy

United Arab Emirates University · Kafrelsheikh University · +5 more institutions

PubMed
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Abstract

The escalating prevalence of multidrug-resistant (MDR) bacteria presents a critical global health challenge, necessitating the urgent development of alternative antimicrobial strategies. Silver nanoparticles (AgNPs) have emerged as promising antimicrobial agents due to their broad-spectrum activity, unique physicochemical properties, and multiple mechanisms of bacterial inhibition. Their nanoscale size, high surface area-to-volume ratio, and ability to generate reactive oxygen species (ROS) make them highly effective against both Gram-positive and Gram-negative bacteria. AgNPs exert their antimicrobial effects through diverse mechanisms, including membrane disruption, protein and DNA interactions, enzymatic…

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55
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21.98
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100%
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188
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Authors

7

Topics & keywords

Topics
Keywords
  • Antimicrobial
  • Multiple drug resistance
  • Bacteria
  • Microbiology
  • Anti-Infective Agents
  • Antibiotic resistance
  • Antibiotics
  • Chemistry
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