Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis
Kunming Medical University · Department of Embryology · +5 more institutions
Abstract
Diabetic wound healing remains a persistent clinical challenge, necessitating the development of effective therapeutic agents and a deeper understanding of regulatory mechanisms. The cyclic heptapeptide FZ1, characterized by favorable biocompatibility, exhibited significantly greater efficacy than rh-bFGF and CyRL-QN15 in promoting cell proliferation and migration. In diabetic wound models, FZ1 markedly accelerated tissue regeneration and stimulated angiogenesis, as indicated by the upregulation of CD31 and α-SMA. Mechanistic investigations combining single-cell RNA sequencing, RNA interference, surface plasmon resonance, and molecular docking revealed that FZ1 directly bound to integrin αvβ3, activating…
Citation impact
- FWCI
- 54.63
- Percentile
- 100%
- References
- 67
Authors
14- LWLitian Wang
Kunming Medical University, Department of Embryology
- ZFZhe Fu
Kunming Medical University, Department of Embryology
- YSYunhan Su
Kunming Medical University, Department of Embryology
- WYWenjie Yin
Kunming Medical University, Department of Embryology
- XWXiangwen Wang
Minzu University of China, State Ethnic Affairs Commission
Topics & keywords
- Chemistry
- Angiogenesis
- Wound healing
- Agonist
- Integrin
- Pharmacology
- Receptor
- Biochemistry