articleNew England Journal of MedicineSep 17, 2025Closed access

Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer

Karolinska University Hospital · Karolinska Institutet · +17 more institutions

PubMed
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Abstract

Background

mutations. However, data from randomized trials are lacking.

Methods

(group B alterations) were eligible for randomization. The primary end point was colorectal cancer recurrence, assessed in a time-to-event analysis, in patients with group A alterations. Secondary end points included colorectal cancer recurrence in patients with group B alterations, disease-free survival, and safety.

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Funding