reviewChemical Society ReviewsJan 1, 2025HYBRID OA

Intermolecular 1,2-difunctionalization of alkenes

Dalian Institute of Chemical Physics · Chinese Academy of Sciences · +5 more institutions

PubMed
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Abstract

Three different reaction modes. Firstly, metal species can add double bonds by employing transition metals; further coupling can then be followed to complete the difunctionalization. Another intriguing approach is that radicals add to the olefins and then are quenched in diverse ways. The ability to continuously introduce diverse functional groups is the most significant feature of this platform. The third mode is that the olefin is transformed into a cationic radical or anionic radical intermediate through single-electron transfer. This strategy is less developed and more novel, but has certain limitations. Driven by the innovation of synthetic chemistry strategies, the difunctionalization of olefins, which…

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