reviewThe LancetSep 1, 2025HYBRID OA

New landscape of the diagnosis of Alzheimer's disease

GBGiovanni B. FrisoniOHOskar HanssonENEmma NicholsVGValentina GaribottoSESuzanne E. Schindler

University of Southern California · Washington University in St. Louis · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individuals, and a leading source of health and social care expenditure for society. Before the advent of biomarkers, post-mortem examination was the only method available to establish a definitive diagnosis. In this first paper of the Series, we review state-of-the-art diagnostic practices and the typical patient journey in specialist settings, where clinicians engage in a differential diagnosis to establish whether Alzheimer's pathology (cerebral deposition of β-amyloid and hyperphosphorylated tau) is a contributor to…

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59
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63.86
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100%
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Authors

18

Topics & keywords

Topics
Keywords
  • Disease
  • Differential diagnosis
  • Diagnostic test
  • Health care
  • MEDLINE
  • Patient care
  • Differential (mechanical device)
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