Glucose-responsive nanozyme hydrogel for glycemic control and catalytic anti-infective therapy in diabetic wound healing

Diabetes-induced impairment in glycemic regulation delays wound healing by promoting bacterial infection, oxidative stress, and vascular injury. To address these challenges, we developed a glucose-activated, self-switchable nanozyme–hydrogel platform capable of intelligent, on-demand insulin release synchronized with blood glucose fluctuations, thereby achieving closed-loop glycemic control while promoting tissue repair. This multifunctional system integrates glucose oxidase (GOx) and insulin within bimetallic Zn-Fe metal organic framework nanoparticles (MOF(Zn-Fe)/GOx/INS), which are embedded in a ROS-responsive hydrogel. Under hyperglycemic conditions, GOx catalyzes glucose oxidation to gluconic acid and H 2…

• NN
  National Natural Science Foundation of China

  Awards: 82322042, 82272248
• NS
  Natural Science Foundation of Guangdong Province for Distinguished Young Scholars

  Award: 2022B1515020089