Turning cold tumors into hot tumors to ignite immunotherapy
Zhengzhou University · First Affiliated Hospital of Zhengzhou University · +1 more institution
Abstract
The revolution in cancer immunotherapy, particularly through immune checkpoint inhibitors (ICIs), underscores the significant role of the tumor microenvironment (TME) in determining therapeutic outcomes. At the heart of this is the classification of tumors into "cold" and "hot", which significantly influences the efficacy of immunotherapy. "Cold" tumors are characterized by scant immune cell infiltration and an immunosuppressive TME, which effectively evades immune detection and resists ICIs. In contrast, "hot" tumors, characterized by abundant immune cells and a proinflammatory environment, are more receptive to immunotherapeutic approaches. This review comprehensively examines the molecular and cellular…
Citation impact
- FWCI
- 25.27
- Percentile
- 100%
- References
- 691
Authors
7- YLYuan‐Tong LiuCorresponding
Zhengzhou University, First Affiliated Hospital of Zhengzhou University
- YWYunlong Wang
Zhengzhou University, Henan Provincial People's Hospital, First Affiliated Hospital of Zhengzhou University
- SWShuo Wang
Zhengzhou University, First Affiliated Hospital of Zhengzhou University
- JLJiajun Li
Zhengzhou University, Henan Provincial People's Hospital, First Affiliated Hospital of Zhengzhou University
- WHWei He
First Affiliated Hospital of Zhengzhou University
Topics & keywords
- Immune system
- Immunotherapy
- Tumor microenvironment
- Cancer immunotherapy
- Melanoma
- Immune checkpoint
- Cancer
- Proinflammatory cytokine