Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential
Wuchang University of Technology · Wuhan University of Science and Technology · +9 more institutions
Abstract
Regulatory T cells (Treg cells or Tregs), a subset of CD4⁺ T cells with immunosuppressive properties, are essential for immune homeostasis and self-tolerance. Characterized by their immunosuppressive capabilities and reliance on the transcription factor Foxp3 (Forkhead box protein P3), Tregs employ multiple mechanisms, including cytokine secretion, metabolic control, and cell contact inhibition, to restrain excessive immune activation to prevent autoimmunity while maintaining tissue repair processes. However, dysregulation in their frequency or function-whether deficiency or hyperactivity-is implicated in diverse pathologies, spanning autoimmune disorders, cancer progression, transplant rejection, and emerging…
Citation impact
- FWCI
- 38.51
- Percentile
- 100%
- References
- 551
Authors
9- LWLingling Wang
Wuchang University of Technology, Wuhan University of Science and Technology
- YLYing Liang
Air Force Medical University
- CZChunxia Zhao
Wuchang University of Technology, Wuhan University of Science and Technology
- PMPeijun Ma
Shanghai Jiao Tong University, Shanghai Mental Health Center
- SZShulin Zeng
Wuchang University of Technology, Wuhan University of Science and Technology
Topics & keywords
- FOXP3
- Autoimmunity
- Immune system
- Immunotherapy
- Cancer immunotherapy
- Homeostasis
- Regulatory T cell
- Transplant rejection