reviewPharmaceuticsOct 15, 2025GOLD OA

Exosome-Based Drug Delivery: A Next-Generation Platform for Cancer, Infection, Neurological and Immunological Diseases, Gene Therapy and Regenerative Medicine

DRDolores R. SerranoFJFrancisco JusteBJBrayan J. AnayaBIBianca I. RamirezSASergio A. Sánchez-Guirales

Universidad Complutense de Madrid · Universidad San Pablo CEU · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Exosomes, naturally derived extracellular vesicles, have emerged as powerful bio-nanocarriers in precision medicine. Their endogenous origin, biocompatibility, and ability to encapsulate and deliver diverse therapeutic payloads position them as transformative tools in drug delivery, gene therapy, and regenerative medicine. This review presents a comprehensive analysis of exosome-based therapeutics across multiple biomedical domains, including cancer, neurological and infectious diseases, immune modulation, and tissue repair. Exosomes derived from stem cells, immune cells, or engineered lines can be loaded with small molecules, RNA, or CRISPR-Cas systems, offering highly specific and low-immunogenic…

Citation impact

51
total citations
FWCI
31.60
Percentile
100%
References
116
Citations per year

Authors

12

Topics & keywords

Topics
Keywords
  • Microvesicles
  • Regenerative medicine
  • Immune system
  • Genetic enhancement
  • Exosome
  • Bench to bedside
  • Clinical trial
  • Translational medicine
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