Bridging the Gap: The Role of Advanced Formulation Strategies in the Clinical Translation of Nanoparticle-Based Drug Delivery Systems

Although nanoparticles (NPs) show tremendous potential in the laboratory, most of them fail to reach clinical applications, highlighting a significant "translational gap" in nanomedicine. This gap is often due to a lack of focus on advanced formulation strategies required to transform NPs into functional drug products. Therefore, this review systematically addresses the crucial role of secondary delivery systems in bridging this gap. We analyze and compare various advanced formulation platforms, such as sterile injectables for the intravenous route, hydrogels for topical delivery, microspheres for the oral route, dry powder formulations for inhalation, and polymer implants for controlled release, and discuss…

• UP
  Universitas Padjadjaran