articleeLightJan 7, 2026DIAMOND OA

Deep-ultraviolet ptychographic pocket-scope (DART): mesoscale lensless molecular imaging with label-free spectroscopic contrast

RWRuihai WangQZQianhao ZhaoJQJulia QuinnLYLiming YangYZYuhui Zhu

University of Connecticut · UConn Health · +3 more institutions

PubMed
Indexed inarxivcrossrefdatacitedoajpubmed

Abstract

The mesoscale characterization of biological specimens has traditionally required compromises between resolution, field-of-view, depth-of-field, and molecular specificity, with most approaches relying on external labels. Here we present the Deep-ultrAviolet ptychogRaphic pockeT-scope (DART), a handheld platform that transforms label-free molecular imaging through intrinsic deep-ultraviolet spectroscopic contrast. By leveraging biomolecules' natural absorption fingerprints and combining them with lensless ptychographic microscopy, DART resolves down to 308-nm linewidths across centimeter-scale areas while maintaining millimeter-scale depth-of-field. The system's virtual error-bin methodology effectively…

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4
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78.56
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99%
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14

Topics & keywords

Topics
Keywords
  • Contrast (vision)
  • Molecular imaging
  • Mesoscale meteorology
  • Phase-contrast imaging
  • Phase retrieval
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