articleNatureDec 10, 2025HYBRID OA

Mapping the genetic landscape across 14 psychiatric disorders

ADAndrew D. GrotzingerJWJosefin WermeWJWouter J. PeyrotOFOleksandr FreiCDChristiaan de Leeuw

University of Colorado Boulder · Amsterdam Neuroscience · +324 more institutions

PubMed
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Abstract

Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar disorder3, genomic methods have revealed that the majority of genetic signal is shared4. While over a hundred pleiotropic loci have been identified by recent cross-disorder analyses5, the full scope of shared and disorder-specific genetic influences remains poorly defined. Here we addressed this gap by triangulating across a suite of cutting-edge statistical and functional genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders (1,056,201 cases). Using genetic…

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Topics & keywords

Topics
Keywords
  • Schizophrenia (object-oriented programming)
  • Psychiatric genetics
  • Bipolar disorder
  • Comorbidity
  • Psychosis
  • Anxiety
  • Genetic association
  • Genetic correlation
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